Enhanced Bassoon Reed
نویسندگان
چکیده
منابع مشابه
Manganese-enhanced MRI reveals structural and functional changes in the cortex of Bassoon mutant mice.
Manganese-enhanced magnetic resonance imaging (ME-MRI) was used to analyze the brain architecture in mice lacking the functional presynaptic active zone protein Bassoon. Anatomical characterization revealed a significant increase in the total brain volume in Bassoon mutants as compared with wild-type mice, which is mainly caused by changes in cortex and hippocampus volume. The measured enlargem...
متن کاملBassoon Controls Presynaptic Autophagy through Atg5
Mechanisms regulating the surveillance and clearance of synaptic proteins are not well understood. Intriguingly, the loss of the presynaptic active zone proteins Piccolo and Bassoon triggers the loss of synaptic vesicles (SVs) and compromises synaptic integrity. Here we report that the destruction of SVs in boutons lacking Piccolo and Bassoon was associated with the induction of presynaptic aut...
متن کاملSynaptic requiem: a duet for Piccolo and Bassoon.
Neurotransmission in the brain critically depends on the maintenance of synapses as well as on regulated synaptic protein turnover. How synaptic proteostasis is held in check has remained largely enigmatic. A new paper in The EMBO Journal reports that the active zone proteins Piccolo and Bassoon put a brake on presynaptic protein turnover by restraining the activity of the E3 ubiquitin ligase S...
متن کاملPiccolo, a Presynaptic Zinc Finger Protein Structurally Related to Bassoon
Piccolo is a novel component of the presynaptic cytoskeletal matrix (PCM) assembled at the active zone of neurotransmitter release. Analysis of its primary structure reveals that Piccolo is a multidomain zinc finger protein structurally related to Bassoon, another PCM protein. Both proteins were found to be shared components of glutamatergic and GABAergic CNS synapses but not of the cholinergic...
متن کاملBassoon Speeds Vesicle Reloading at a Central Excitatory Synapse
Sustained rate-coded signals encode many types of sensory modalities. Some sensory synapses possess specialized ribbon structures, which tether vesicles, to enable high-frequency signaling. However, central synapses lack these structures, yet some can maintain signaling over a wide bandwidth. To analyze the underlying molecular mechanisms, we investigated the function of the active zone core co...
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ژورنال
عنوان ژورنال: Eurasian Journal of Music and Dance
سال: 2019
ISSN: 2651-4818
DOI: 10.31722/ejmd.584381